CD324 (E-cadherin) Rat, Clone: DECMA-1, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-3249-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258607

Quantity Price
1 £ 176.7 / 500µg
EU Stock 2
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Description and Specification

Specification

Format Purified
Concentration 1mg/mL
Isotype IgG1
Species Reactivity Canine, Human, Mouse
Primary or Secondary Primary
Conjugate Unlabeled
Applications Flow Cytometry
Applications Functional Assay
Host Species Rat
Quantity 500μg
Regulatory Status RUO
Gene Alias epithelial cadherin
Storage Requirements Store at 2-8°C.
Clone DECMA-1
Monoclonal or Polyclonal Monoclonal
Antigen CD324 (E-cadherin)
Formulation aqueous buffer, no sodium azide

The monoclonal antibody DECMA-1 recognizes mouse, human and canine CD324 also known as E-cadherin (Epithelial cadherin) or uvomorulin. Like the other cadherin family members P and N cadherin, E-cadherin is a transmembrane glycoprotein involved in intercellular adhesion. These proteins share a common basic structure. The extracellular portions of the proteins are largely composed of repeating domains, each with two consensus Ca2+-binding motifs. The cytoplasmic domain interacts with a-, b-, and g-catenins and actinins. These catenins connect E-cadherin with the cytoskeleton. Expression is found in most epidermal cells including melanocytes and kerotinocytes. E-cadherin is localized at the intercellular boundaries of epithelial cells in several tissues, and is thought to play a role in maintenance of tissue integrity. Loss of E-cadherin function has been implicated in the progression of a variety of cancers.

E-Cadherin protein is sensitive to trypsin treatment, so exposure to trypsin should be minimized or avoided.

The monoclonal antibody DECMA-1 has been shown to have functional activity by disrupting adhesion in human, mouse and dog cells.