CD319 (CRACC) Mouse anti-Human, PerCP-eFluor 710, Clone: 162, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-2229-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15589216

Quantity Price
1 £ 91.11 / 25 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Species Reactivity Human
Regulatory Status RUO
Primary or Secondary Primary
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Concentration 5μL (0.5μg)/test
Clone 162
Applications Flow Cytometry
Conjugate PerCP-eFluor 710
Monoclonal or Polyclonal Monoclonal
Format Conjugated
Gene Alias CD2 like Receptor activating cytotoxic cells, CS1, SLAMF7
Host Species Mouse
Isotype IgG2b
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD319 (CRACC)
Quantity 25 tests

The monoclonal antibody 162 recognizes CRACC (CD2 like receptor for activating cytotoxic cells) also known as CD319 and CS1. It is a member of the SLAM receptor family. CRACC is a 66kDa glycosylated transmembrane protein which contains a cytoplasmic ITSM domain (Immunoreceptor Tyrosine-based Switch Motif). It is this domain, found in other proteins such as CD244 and NTB-A, that interacts with SH2 containing proteins such as SAP. Interestingly the ITSM domain in CRACC is SAP independent. Instead EAT-2 acts as the signaling molecule for CRACC. This has profound impact for patients with X-linked lymphoproliferative disease (contains a SAP mutation). It should be noted that a splice variant has been reported which deletes the ITSM domain.