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CD319 (CRACC) Mouse anti-Human, PerCP-eFluor 710, Clone: 162, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-2229-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15599216

  • £195.05 / 100 tests


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For Research Use Only.


Description

Description

The monoclonal antibody 162 recognizes CRACC (CD2 like receptor for activating cytotoxic cells) also known as CD319 and CS1. It is a member of the SLAM receptor family. CRACC is a 66kDa glycosylated transmembrane protein which contains a cytoplasmic ITSM domain (Immunoreceptor Tyrosine-based Switch Motif). It is this domain, found in other proteins such as CD244 and NTB-A, that interacts with SH2 containing proteins such as SAP. Interestingly the ITSM domain in CRACC is SAP independent. Instead EAT-2 acts as the signaling molecule for CRACC. This has profound impact for patients with X-linked lymphoproliferative disease (contains a SAP mutation). It should be noted that a splice variant has been reported which deletes the ITSM domain.
Specifications

Specifications

CD319 (CRACC)
162
PerCP-eFluor™ 710
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
Flow Cytometry
5μL (0.5μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
CD2 like Receptor activating cytotoxic cells, CS1, SLAMF7
IgG2b
RUO
Primary
Human
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