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CD317 (BST2/PDCA-1) Rat anti-Mouse, Clone: eBio927, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-3172-81

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15208607

  • £66.65 / 50µg


Estimated Shipment
29-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

The eBio927 monoclonal antibody reacts with PDCA-1 (BST2, CD317), a specific marker of plasmacytoid dendritic cells (pDC), also known as type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPCs are typically CD11c+, CD11b-, B220+, Ly-6C+, and CD62L+. PDCA-1 is predominantly expressed by IPCs in the naïve mouse which represents a very minor population (<0.5%) of splenocytes. It is upregulated on numerous cell types following stimulation which triggers an IFN response. PDCA-1 cycles between cell surface and intracellular compartments and may function to regulate trafficking of secreted cytokines. PDCA-1 (BST2) is the protein recognized by antibody 120G8.

The eBio927 monoclonal antibody has also been shown to have functional activity. The epitope recognized by eBio927 is distinct from eBio129c; thus, the antibodies can be used to costain, purify and identify pDCs.
Specifications

Specifications

CD317 (BST2/PDCA-1)
eBio927
Unconjugated
Purified
Rat
50μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
plasmacytoid DC Ag-1
IgG2b
RUO
Primary
Murine