CD317 (BST2/PDCA-1) Mouse anti-Human, Clone: 26F8, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-3179-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15238607

Quantity Price
1 £ 158.36 / 100µg
EU Stock 6
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Description and Specification

Specification

Concentration 1mg/mL
Formulation aqueous buffer, no sodium azide
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Format Purified
Primary or Secondary Primary
Clone 26F8
Antigen CD317 (BST2/PDCA-1)
Species Reactivity Human
Quantity 100μg
Regulatory Status RUO
Conjugate Unlabeled
Host Species Mouse
Storage Requirements Store at 2-8°C.
Applications Flow Cytometry
Applications Functional Assay

This 26F8 monoclonal antibody reacts with human CD317 (also known as BST2 and tetherin). CD317 is a 30-36kDa type II transmembrane protein expressed on B cells and bone marrow stromal cells. Although reports have indicated that CD317 mRNA is detectable in activated T cells, protein expression in primary T cells and macrophages is undetectable. Moreover, certain T cell lines, such as Jurkat, do not express detectable levels of CD317 protein. CD317 has been associated with pre-B cell growth and the terminal differentiation of plasma B cells. More recently, this molecule has been reported to prevent HIV-1 virion release from the surface of infected cells, leading to reuptake and degradation of the virus. This activity is inhibited by the HIV-1 accessory protein Vpu. CD317 has been identified as the ligand for the ILT7 receptor.