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CD317 (BST2/PDCA-1) Mouse anti-Human, Clone: 26F8, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-3179-82

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15238607

  • £158.36 / 100µg


EU Stock 6
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Disclaimers:

For Research Use Only.


Description

Description

This 26F8 monoclonal antibody reacts with human CD317 (also known as BST2 and tetherin). CD317 is a 30-36kDa type II transmembrane protein expressed on B cells and bone marrow stromal cells. Although reports have indicated that CD317 mRNA is detectable in activated T cells, protein expression in primary T cells and macrophages is undetectable. Moreover, certain T cell lines, such as Jurkat, do not express detectable levels of CD317 protein. CD317 has been associated with pre-B cell growth and the terminal differentiation of plasma B cells. More recently, this molecule has been reported to prevent HIV-1 virion release from the surface of infected cells, leading to reuptake and degradation of the virus. This activity is inhibited by the HIV-1 accessory protein Vpu. CD317 has been identified as the ligand for the ILT7 receptor.
Specifications

Specifications

CD317 (BST2/PDCA-1)
26F8
Unconjugated
Purified
IgG1
RUO
Primary
Human
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
Murine
100μg
Store at 2-8°C.
Monoclonal
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