CD317 (BST2/PDCA-1) Mouse anti-Human, Clone: 26F8, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-3179-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15228607

Quantity Price
1 £ 72.77 / 25µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Quantity 25μg
Concentration 1mg/mL
Applications Flow Cytometry
Applications Functional Assay
Formulation aqueous buffer, no sodium azide
Storage Requirements Store at 2-8°C.
Format Purified
Primary or Secondary Primary
Antigen CD317 (BST2/PDCA-1)
Host Species Mouse
Isotype IgG1
Conjugate Unlabeled
Regulatory Status RUO
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Clone 26F8

This 26F8 monoclonal antibody reacts with human CD317 (also known as BST2 and tetherin). CD317 is a 30-36kDa type II transmembrane protein expressed on B cells and bone marrow stromal cells. Although reports have indicated that CD317 mRNA is detectable in activated T cells, protein expression in primary T cells and macrophages is undetectable. Moreover, certain T cell lines, such as Jurkat, do not express detectable levels of CD317 protein. CD317 has been associated with pre-B cell growth and the terminal differentiation of plasma B cells. More recently, this molecule has been reported to prevent HIV-1 virion release from the surface of infected cells, leading to reuptake and degradation of the virus. This activity is inhibited by the HIV-1 accessory protein Vpu. CD317 has been identified as the ligand for the ILT7 receptor.