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CD317 (BST2/PDCA-1) Mouse anti-Human, Alexa Fluor 488, Clone: 26F8, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-3179-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15580207

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Disclaimers:

For Research Use Only.


Description

Description

This 26F8 monoclonal antibody reacts with human CD317 (also known as BST2 and tetherin). CD317 is a 30-36kDa type II transmembrane protein expressed on B cells and bone marrow stromal cells. Although reports have indicated that CD317 mRNA is detectable in activated T cells, protein expression in freshly isolated primary T cells and macrophages is undetectable. Moreover, certain T cell lines, such as Jurkat, do not express detectable levels of CD317 protein. However, CD317 expression can be induced in many cell types (e.g., T and B cells, 293T, and HeLa) by IFNα treatment. CD317 has been associated with pre-B cell growth and the terminal differentiation of plasma B cells. More recently, this molecule has been reported to prevent HIV-1 virion release from the surface of infected cells, leading to reuptake and degradation of the virus. This activity is inhibited by the HIV-1 accessory protein Vpu. CD317 has been identified as the ligand for the ILT7 receptor.
Specifications

Specifications

CD317
26F8
Alexa Fluor™ 488
Conjugated
IgG1
RUO
Primary
Human
Flow Cytometry
5μL (0.25μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal