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CD314 (NKG2D), Functional Grade, clone: MI-6 (MI6), eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-5880-85

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15278667

  • £180.95 / 500µg


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Description

Description

Description: The MI-6 monoclonal antibody reacts with the mouse NKG2D, a lectin-like molecule expressed on both human and mouse NK cells. Mouse NKG2D binds to retinoic acid-inducible RAE-1 alpha, beta, gamma, delta, epsilon and the minor histocompatibility molecule H60 and has the ability to costimulate multiple NK activation receptors, through the DAP12/DAP10 adaptor molecules. NKG2D is expressed by all spleen and liver NK cells, NK1.1(+) thymocytes, in vitro activated LAK cells, and a subset of splenic NKT cells.Applications Reported: This MI-6 (MI6) antibody has been reported for use in flow cytometric analysis. Furthermore, engagement of NKG2D with the MI-6 monoclonal antibody has been demonstrated to block NKG2D-mediated cytolysis, both in vitro and in vivo .Applications Tested: This MI-6 (MI6) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Storage and handling: Use in a sterile environment.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
Specifications

Specifications

CD314 (NKG2D)
MI-6 (MI6)
Unconjugated
Purified
Rat
500μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
KLRK1
IgG2a, lambda
RUO
Primary
Murine
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