CD314 (NKG2D) Mouse anti-Human, PE-Cy7, Clone: 1D11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 25-5878-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15558586

Quantity Price
1 £ 174.09 / 100 tests
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Isotype IgG1
Species Reactivity Human
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Regulatory Status RUO
Primary or Secondary Primary
Antigen CD314 (NKG2D)
Gene Alias KLRK1
Applications Flow Cytometry
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Conjugate PE-Cy7
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test
Clone 1D11
Quantity 100 tests

The 1D11 monoclonal antibody reacts with the human NKG2D, a 42kDa lectin-like molecule expressed by NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.