CD314 (NKG2D) Mouse anti-Human, PE, Clone: 1D11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5878-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15567036

Quantity Price
1 £ 66.65 / 25 tests
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.125μg)/test
Antigen CD314 (NKG2D)
Isotype IgG1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias KLRK1
Clone 1D11
Applications Flow Cytometry
Regulatory Status RUO
Primary or Secondary Primary
Conjugate PE
Quantity 25 tests
Format Conjugated
Host Species Mouse

The 1D11 monoclonal antibody reacts with the human NKG2D, a 42kDa lectin-like molecule expressed by NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.