CD314 (NKG2D) Mouse anti-Human, Clone: 1D11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5878-80

Product Code. 15297537

Disclaimers:

For Research Use Only.

Description

The 1D11 monoclonal antibody reacts with the human NKG2D, a 42kDa lectin-like molecule expressed by NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.

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Specifications

• Antigen: CD314 (NKG2D)
• Clone: 1D11
• Conjugate: Unlabeled
• Format: Purified
• Host Species: Murine
• Quantity: 25μg
• Storage Requirements: Store at 2-8°C.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Immunoprecipitation
• Concentration: 0.5mg/mL
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Gene Alias: KLRK1
• Isotype: IgG1
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human