CD314 (NKG2D) Mouse anti-Human, Biotin, Clone: 1D11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-5878-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15219889

Quantity Price
1 £ 152.25 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Clone 1D11
Concentration 0.5mg/mL
Isotype IgG1
Gene Alias KLRK1
Species Reactivity Human
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Mouse
Quantity 100μg
Antigen CD314 (NKG2D)
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze.
Conjugate Biotin
Applications Flow Cytometry
Primary or Secondary Primary

The 1D11 monoclonal antibody reacts with the human NKG2D, a 42kDa lectin-like molecule expressed by NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.