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CD307e (FcRL5) Mouse anti-Human, eFluor 660, Clone: 509F6, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-3078-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15569926

  • £78.88 / 25 tests


Estimated Shipment date
from Supplier 28-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The 509F6 monoclonal antibody reacts with human CD307e which is also known as Fc receptor-like 5, FcRL5, FcRH5, or IRTA2. CD307e is a surface protein expressed selectively on naïve mature B cells and on bone marrow plasma cells, and binds to all IgG isotypes. CD307e functions as an inhibitory coreceptor on mature B cells in humans via the recruitment of the phosphatase SHP-1 to its two immunoreceptor tyrosine-based inhibitory motifs (ITIM). CD307e can also exist in soluble form and high levels of soluble CD307e have been detected in the blood of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma. Because surface-bound CD307e is also highly-expressed on malignant B cells from multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma patients, CD307e may be a useful therapeutic target for the treatment of these cancers.
Description & Specifications

Specifications

CD307e (FcRL5)
509F6
eFluor 660
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (1.0μg)/test
Conjugated
Fc receptor-like 5, IRTA2
IgG2a
RUO
Primary
Human