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CD307e (FcRL5), eFluor 660, clone: 509F6, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-3078-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15579926

  • £199.07 / 100 tests


Estimated Shipment date
from Supplier 27-02-2018
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Disclaimers:

For Research Use Only.


Description

Description

Description: The 509F6 monoclonal antibody reacts with human CD307e which is also known as Fc receptor-like 5, FcRL5, FcRH5, or IRTA2. CD307e is a surface protein expressed selectively on naive mature B cells and on bone marrow plasma cells, and binds to all IgG isotypes. CD307e functions as an inhibitory coreceptor on mature B cells in humans via the recruitment of the phosphatase SHP-1 to its two immunoreceptor tyrosine-based inhibitory motifs (ITIM). CD307e can also exist in soluble form and high levels of soluble CD307e have been detected in the blood of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma. Because surface-bound CD307e is also highly-expressed on malignant B cells from multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma patients, CD307e may be a useful therapeutic target for the treatment of these cancers.Applications Reported: This 509F6 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 509F6 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (1 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD307e (FcRL5)
509F6
eFluor 660
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (1.0μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Fc receptor-like 5, IRTA2
IgG2a
RUO
Primary
Human
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