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CD307d (FcRL4) Mouse anti-Human, PerCP-eFluor 710, Clone: 413D12, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-3079-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15549236

  • £87.96 / 25 tests


Estimated Shipment date
from Supplier 28-06-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The 413D12 monoclonal antibody reacts with human CD307d, which is also known as FcRL4, Fc receptor-like 4, FcRH4, IRTA4, or IGFP2. CD307d is an inhibitory receptor that is highly expressed on a subset of memory B cells resident in epithelial tissues and marginal zones of mucosal lymphoid tissues such as tonsils. CD307d has been shown to recruit the phosphatase SHP-1, thereby acting as an inhibitory receptor in B cells. CD307d is homologous to FcgammaRI and specifically binds IgA. To date, CD307d is the only known inhibitory receptor for IgA. Expression of CD307d is increased on memory B cells from patients with chronic infections such as HIV, suggesting that enhanced expression of inhibitory receptors, such as CD307d, may contribute to the inefficiency of antibody responses against HIV.
Description & Specifications

Specifications

CD307d (FcRL4)
413D12
PerCP-eFluor 710
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.25μg)/test
Conjugated
Fc receptor-like 4, IRTA1, IGFP2, FcRH4
IgG2b
RUO
Primary
Human