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CD307d (FcRL4) Mouse anti-Human, PerCP-eFluor 710, Clone: 413D12, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-3079-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15549236

  • £87.96 / 25 tests


Estimated Shipment date
from Supplier 27-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The 413D12 monoclonal antibody reacts with human CD307d, which is also known as FcRL4, Fc receptor-like 4, FcRH4, IRTA4, or IGFP2. CD307d is an inhibitory receptor that is highly expressed on a subset of memory B cells resident in epithelial tissues and marginal zones of mucosal lymphoid tissues such as tonsils. CD307d has been shown to recruit the phosphatase SHP-1, thereby acting as an inhibitory receptor in B cells. CD307d is homologous to FcgammaRI and specifically binds IgA. To date, CD307d is the only known inhibitory receptor for IgA. Expression of CD307d is increased on memory B cells from patients with chronic infections such as HIV, suggesting that enhanced expression of inhibitory receptors, such as CD307d, may contribute to the inefficiency of antibody responses against HIV.
Specifications

Specifications

CD307d (FcRL4)
413D12
PerCP-eFluor 710
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.25μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Fc receptor-like 4, IRTA1, IGFP2, FcRH4
IgG2b
RUO
Primary
Human