CD304 Rat anti-Mouse, PE-eFluor 610, Clone: 3DS304M, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 61-3041-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15510487

Quantity Price
1 £ 237.85 / 100µg
Estimated Shipment date
from Supplier 03-05-2017
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Host Species Rat
Quantity 100μg
Conjugate PE-eFluor 610
Regulatory Status RUO
Primary or Secondary Primary
Applications Flow Cytometry (Intracellular Staining)
Antigen CD304
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Conjugated
Clone 3DS304M
Isotype IgG2a
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Gene Alias Nrp-1, NP-1, BDCA-4
Concentration 0.2mg/mL

The monoclonal antibody 3DS304M recognizes mouse CD304 (Neuropilin-1), a type 1 transmembrane glycoprotein present on the surface of multiple cell types, including: regulatory T cells (Treg), NKT cells, DC, certain types of stem cells, neurons, endothelial cells, and some neoplastic cells. Neuropilin-1, in complex with plexins, serves as a co-receptor for type 3 semaphorins in growing neurons. It is also involved in the process of angiogenesis being a part of a functional receptor for VEGF in endothelial cells. In mice, Neuropilin-1 is expressed on thymus-derived natural Treg but not peripherally induced Treg. In addition, transient expression on recently activated non-regulatory T cells has been observed. Neuropilin-1 has been used as a marker of recent thymic emigrants in the mouse iNKT cell population. It has been shown that Neuropilin-1 forms a complex with TGF beta receptors, activating the latent form of TGF beta (LAP-TGF beta 1) and augmenting canonical Smad2/3 signaling.

This 3DS304M antibody will recognize formaldehyde-fixed as well as methanol-treated epitopes.