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CD304 (Neuropilin-1) Rat anti-Mouse, PE, Clone: 3DS304M, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-3041-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15586956

  • £78.88 / 25µg


Estimated Shipment date
from Supplier 01-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal antibody 3DS304M recognizes mouse CD304 (Neuropilin-1), a type 1 transmembrane glycoprotein present on the surface of multiple cell types, including: regulatory T cells (Treg), NKT cells, DC, certain types of stem cells, neurons, endothelial cells, and some neoplastic cells. Neuropilin-1, in complex with plexins, serves as a co-receptor for type 3 semaphorins in growing neurons. It is also involved in the process of angiogenesis being a part of a functional receptor for VEGF in endothelial cells. In mice, Neuropilin-1 is expressed on thymus-derived natural Treg but not peripherally induced Treg. In addition, transient expression on recently activated non-regulatory T cells has been observed. Neuropilin-1 has been used as a marker of recent thymic emigrants in the mouse iNKT cell population. It has been shown that Neuropilin-1 forms a complex with TGF beta receptors, activating the latent form of TGF beta (LAP-TGF beta 1) and augmenting canonical Smad2/3 signaling.

This 3DS304M antibody will recognize formaldehyde-fixed as well as methanol-treated epitopes.
Description & Specifications

Specifications

CD304 (Neuropilin-1)
3DS304M
PE
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
Conjugated
Nrp-1, NP-1, BDCA-4
IgG2a
RUO
Primary
Murine