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CD304 (Neuropilin-1) Rat anti-Mouse, Clone: XML1Y1, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-3042-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15507446

  • £67.82 / 25µg


Estimated Shipment date
from Supplier 25-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody XML1Y1 recognizes CD304 (Neuropilin-1), a type 1 transmembrane glycoprotein present on the surface of multiple cell types, including: regulatory T cells (Tregs), NKT cells, DC, certain types of stem cells, neurons, endothelial cells, and some neoplastic cells. Neuropilin-1, in complex with plexins, serves as a co-receptor for type 3 semaphorins in growing neurons. It is also involved in the process of angiogenesis being a part of a functional receptor for VEGF in endothelial cells. In mouse Neuropilin-1 is expressed on thymus-derived natural Tregs but not peripherally induced Treg cells. In addition, transient expression on recently activated non-regulatory T cells has been observed. Neuropilin-1 has been used as a marker of recent thymic emigrants in the mouse iNKT cell population. It has been shown that Neuropilin-1 forms a complex with TGF beta receptors, activating TGF beta latent form (LAP-TGF beta 1) and augmenting canonic Smad2/3 signaling.

This XML1Y1 antibody recognizes neuropilin-1 isoforms 1 and 2.
Specifications

Specifications

CD304 (Neuropilin-1)
XML1Y1
Unconjugated
Purified
Rat
25μg
Store at 2-8°C.
Monoclonal
Immunohistochemistry (Frozen)
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Nrp-1, NP-1, BDCA-4
IgG2a
RUO
Primary
Murine