CD304 (Neuropilin-1), clone: XML1Y1, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 14-3042-80
Code : NEW
Additional Details : Weight : 0.09500kg
DescriptionDescription: The monoclonal antibody XML1Y1 recognizes CD304 (Neuropilin-1), a type 1 transmembrane glycoprotein present on the surface of multiple cell types, including: regulatory T cells (Tregs), NKT cells, DC, certain types of stem cells, neurons, endothelial cells, and some neoplastic cells. Neuropilin-1, in complex with plexins, serves as a co-receptor for type 3 semaphorins in growing neurons. It is also involved in the process of angiogenesis being a part of a functional receptor for VEGF in endothelial cells. In mouse Neuropilin-1 is expressed on thymus-derived natural Tregs but not peripherally induced Treg cells. In addition, transient expression on recently activated non-regulatory T cells has been observed. Neuropilin-1 has been used as a marker of recent thymic emigrants in the mouse iNKT cell population. It has been shown that Neuropilin-1 forms a complex with TGF beta receptors, activating TGF beta latent form (LAP-TGF beta 1) and augmenting canonic Smad2/3 signaling.This XML1Y1 antibody recognizes neuropilin-1 isoforms 1 and 2.Applications Reported: This XML1Y1 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, and immunocytochemistry.Applications Tested: This XML1Y1 antibody has been tested by immunohistochemistry of acetone-fixed frozen tissue sections and can be used at less than or equal to 1 ug/mL. This XML1Y1 antibody has been tested by immunocytochemistry of methanol-fixed bEND3 cells and can be used at less than or equal to 1 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
|Store at 2-8°C.|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Nrp-1, NP-1, BDCA-4|
For Research Use Only.