CD304 (Neuropilin-1) Rat anti-Mouse, Clone: XML1Y1, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-3042-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15507446

Quantity Price
1 £ 67.82 / 25µg
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Conjugate Unlabeled
Applications Immunocytochemistry
Applications Immunohistochemistry (Frozen)
Concentration 0.5mg/mL
Host Species Rat
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG2a
Species Reactivity Mouse
Antigen CD304 (Neuropilin-1)
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C.
Regulatory Status RUO
Quantity 25μg
Clone XML1Y1
Format Purified
Gene Alias Nrp-1, NP-1, BDCA-4

The monoclonal antibody XML1Y1 recognizes CD304 (Neuropilin-1), a type 1 transmembrane glycoprotein present on the surface of multiple cell types, including: regulatory T cells (Tregs), NKT cells, DC, certain types of stem cells, neurons, endothelial cells, and some neoplastic cells. Neuropilin-1, in complex with plexins, serves as a co-receptor for type 3 semaphorins in growing neurons. It is also involved in the process of angiogenesis being a part of a functional receptor for VEGF in endothelial cells. In mouse Neuropilin-1 is expressed on thymus-derived natural Tregs but not peripherally induced Treg cells. In addition, transient expression on recently activated non-regulatory T cells has been observed. Neuropilin-1 has been used as a marker of recent thymic emigrants in the mouse iNKT cell population. It has been shown that Neuropilin-1 forms a complex with TGF beta receptors, activating TGF beta latent form (LAP-TGF beta 1) and augmenting canonic Smad2/3 signaling.

This XML1Y1 antibody recognizes neuropilin-1 isoforms 1 and 2.