CD300e (IREM-2) Mouse anti-Human, PE, Clone: UP-H2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-3007-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15566956

Quantity Price
1 £ 97.22 / 25 tests
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Quantity 25 tests
Antigen CD300e (IREM-2)
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Clone UP-H2
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Format Conjugated
Host Species Mouse
Gene Alias IREM2, CLM-2
Isotype IgG1
Species Reactivity Human
Concentration 5μL (0.25μg)/test
Conjugate PE
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The monoclonal antibody UP-H2 recognizes human IREM-2 (immune receptor expressed in monocytic derived cells) also known as LMIR6, and unofficially CD300E and CD300LE. It is a member of the CMRF-35 family. This 34kDa Ig-like containing receptor is an activating receptor and through it’s charged residues in the cytokplasmic domain interacts with ITAM containing adaptor proteins like DAP12. Expression is found exclusively on monocytes and myeloid DC’s. Expression may be transient as differentiation of monocytes leads to down regulation of IREM-2 yet expression is found on mature DCs. It has been also noted that myeloid cell lines such as THP-1 and U937 do not express IREM-2.
In vitro addition of UP-H2 antibody either soluble or crosslinked stimulates monocytes.