missing translation for 'onlineSavingsMsg'
Learn More

CD3 Rat anti-Mouse, Biotin, Clone: 17A2, eBioscience™

Rat Monoclonal Antibody

£35.11 - £89.25

Specifications

Antigen CD3
Clone 17A2
Target Species Mouse
Conjugate Biotin
Isotype IgG2b, kappa
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15587306 View Documents Affymetrix eBioscience
13-0032-80
25 μg £35.11
25µg View alternative products
Save Up to 
»
Estimated Shipment date
from Supplier 14-05-2020
Please to purchase this item. Need a web account? Register with us today!
15597306 View Documents Affymetrix eBioscience
13-0032-82
100 μg £89.25
100µg View alternative products
Save Up to 
»
EU Stock 3 Please to purchase this item. Need a web account? Register with us today!
Description

Description

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Specifications

Specifications

CD3
Mouse
IgG2b, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
17A2
Biotin
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.