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CD3 Mouse anti-Rat, Clone: eBioG4.18 (G4.18), eBioscience™

Mouse Monoclonal Antibody

£38.87 - £144.00

Specifications

Antigen CD3
Clone eBioG4.18 (G4.18)
Target Species Rat
Conjugate Unconjugated
Isotype IgG3, kappa
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15587406
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Affymetrix eBioscience
14-0030-81
50 μg
£38.87
50µg
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Estimated Shipment
02-12-2020
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10453940
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Affymetrix eBioscience
14-0030-82
100 μg
£63.00
Each
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Estimated Shipment
02-12-2020
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15597406
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Affymetrix eBioscience
14-0030-85
500 μg
£144.00
500µg
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Estimated Shipment
02-12-2020
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Description

Description

Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Specifications

Specifications

CD3
Rat
IgG3, kappa
Monoclonal
Liquid
Antibody
4° C
eBioG4.18 (G4.18)
Unconjugated
Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.