CD3 Mouse anti-Rat, APC, Clone: G4.18, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-0030-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15320550

Quantity Price
1 £ 42.77 / 25µg
EU Stock 4
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Description and Specification

Specification

Format Conjugated
Host Species Mouse
Species Reactivity Rat
Monoclonal or Polyclonal Monoclonal
Isotype IgG3
Gene Alias T3
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate APC
Quantity 25μg
Concentration 0.2mg/mL
Primary or Secondary Primary
Antigen CD3
Regulatory Status RUO
Clone eBioG4.18 (G4.18)
Applications Flow Cytometry
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The eBioG4.18 monoclonal antibody recognizes the rat CD3 protein. CD3 is a critical component of the T-cell receptor (TCR) and is a marker of the T-cell lineage. CD3 is a complex of several subunits and, upon binding of a TCR ligand, participates in transduction of signals from the TCR to the nucleus which results in a variety of cellular responses including transcription of IL-2 and clonal expansion. \i{in vitro\i}, immobilized G4.18 monoclonal antibody has been demonstrated to activate T cells, while soluble G4.18 inhibited allogeneic mixed-lymphocyte proliferative responses and cell-mediated cytotoxicity to allogeneic target cells. \i{in vivo\i}, G4.18 was demonstrated to induce long-term specific tolerance to an organ allograft.