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CD3 Mouse anti-Human, Functional Grade, Clone: OKT3, eBioscience™

Mouse Monoclonal Antibody

£71.75 - £215.00

Specifications

Antigen CD3
Clone OKT3
Target Species Human
Conjugate Functional Grade
Isotype IgG2a, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15171506 View Documents Affymetrix eBioscience
16-0037-85
500 μg £215.00
500µg View alternative products
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15288347 View Documents Affymetrix eBioscience
16-0037-81
50 μg £71.75
50µg View alternative products
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EU Stock 16 Please to purchase this item. Need a web account? Register with us today!
Description

Description

2 μm post- manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Specifications

Specifications

CD3
Human
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C
OKT3
Functional Grade
Flow Cytometry, Functional Assay
Primary
Monoclonal
TBS with no preservative; pH 8.0
RUO