CD290 (TLR10) Mouse anti-Human, PE, Clone: 3C10C5, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 12-2909-42
Code : NEW
Additional Details : Weight : 0.23750kg
DescriptionThis 3C10C5 monoclonal antibody reacts with human CD290, which is also known as Toll-like receptor 10 (TLR10). This type I transmembrane glycoprotein is expressed on B cells, monocytes, regulatory T cells (Tregs), and plasmacytoid dendritic cells. Moreover, CD290 expression is dependent on Foxp3 and NFAT in Tregs. Studies demonstrate that CD290 can self-dimerize, as well as heterodimerize with other members of the TLR family such as TLR1 and TLR2. Ligand binding results in association of the receptor with the adapter molecule MyD88 and subsequent activation of signaling pathways. Although the ligands of CD290 remain undefined, this receptor has been associated with the immune response against microbial and fungal infection and autoimmune diseases such as Crohn’s disease and systemic lupus erythematosous.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|