CD290 (TLR10) Mouse anti-Human, PE, Clone: 3C10C5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-2909-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15536956

Quantity Price
1 £ 195.05 / 100 tests
EU Stock 5
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD290 (TLR10)
Format Conjugated
Quantity 100 tests
Isotype IgG1
Species Reactivity Human
Host Species Mouse
Concentration 5μL (0.25μg)/test
Clone 3C10C5
Conjugate PE
Primary or Secondary Primary
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Regulatory Status RUO

This 3C10C5 monoclonal antibody reacts with human CD290, which is also known as Toll-like receptor 10 (TLR10). This type I transmembrane glycoprotein is expressed on B cells, monocytes, regulatory T cells (Tregs), and plasmacytoid dendritic cells. Moreover, CD290 expression is dependent on Foxp3 and NFAT in Tregs. Studies demonstrate that CD290 can self-dimerize, as well as heterodimerize with other members of the TLR family such as TLR1 and TLR2. Ligand binding results in association of the receptor with the adapter molecule MyD88 and subsequent activation of signaling pathways. Although the ligands of CD290 remain undefined, this receptor has been associated with the immune response against microbial and fungal infection and autoimmune diseases such as Crohn’s disease and systemic lupus erythematosous.