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CD29 (Integrin beta 1) Mouse anti-Human, PE, Clone: TS2/16, eBioscience™

Mouse Monoclonal Antibody

£71.75 - £152.00

Specifications

Antigen CD29 (Integrin beta 1)
Clone TS2/16
Target Species Human
Conjugate PE
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15576746 View Documents Affymetrix eBioscience
12-0299-41
25 Tests £71.75
25 tests View alternative products
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Estimated Shipment date
from Supplier 06-04-2020
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15586746 View Documents Affymetrix eBioscience
12-0299-42
100 Tests £152.00
100 tests View alternative products
Save Up to 
»
Estimated Shipment date
from Supplier 06-05-2020
Please to purchase this item. Need a web account? Register with us today!
Description

Description

CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.
Specifications

Specifications

CD29 (Integrin beta 1)
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
TS2/16
PE
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.