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CD289 (TLR9) Monoclonal Antibody (eB72-1665), APC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

£115.00 - £296.00

Specifications

Antigen CD289 (TLR9)
Clone eB72-1665
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15528236
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Affymetrix eBioscience
17-9099-80
25 μg
£115.00
25µg
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Estimated Shipment: 09-04-2024
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15538236
View Documents Promotion Details
Affymetrix eBioscience
17-9099-82
100 μg
£296.00
100µg
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Estimated Shipment: 08-04-2024
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Description

Description

Description: eB72-1665 is generated against a portion of human toll-like receptor 9 (aa 273-288), a molecule reported to be expressed predomitly intracellularly. TLR9 is a ∽115-120 kDa molecule, which mediates response to unmethylated CpG dinucleotides in bacterial DNA. CpG DNA induces a strong T-helper-1-like inflammatory response and the proliferation of TLR9-positive human B cells. When stimulated with CpG DNA, TLR9-deficient (TLR9-/-) mice lacked splenocyte proliferation, inflammatory cytokine production from macrophages, and dendritic cell maturation, as compared with normal mice. To date, at least twelve members of the Toll family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Members of the TLR family are involved in recognition and response to different microbial components including lipoproteins, peptidoglycans, and nucleic acids and play important roles in innate immunity and inflammation. TLR9 is not detected by flow cytometry using this antibody on lysed whole human blood and/or isolated human PBMC stained for cell surface or intracellular TLR9. This may be due to limitations of antigen detection by flow cytometry. Human pDCs matured in the presence of IL-3 have been reported to stain with eB72-1665 by immunofluorescence microscopy (Nat Immunol. 5:190).

CD289 (TLR9) Monoclonal antibody specifically detects CD289 (TLR9) in Human samples. It is validated for Flow Cytometry.
Specifications

Specifications

CD289 (TLR9)
0.2 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
CD289; Tlr9; toll like receptor 9; toll-like receptor 9; UNQ5798/PRO19605
Tlr9
Primary
4° C, store in dark, DO NOT FREEZE!
Tlr9
eB72-1665
Flow Cytometry
APC
Rat
Human
Q9NR96
54106
IgG2a κ
Affinity chromatography
Antibody
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