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CD284 (TLR4) Mouse anti-Mouse, Alexa Fluor 488, Clone: UT41, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-9041-80

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15362080

  • £103.33 / 25µg


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For Research Use Only.


Description

Description

The UT41 monoclonal antibody was generated against BaF3 cells overexpressing mouse TLR4. So far, at least twelve members of the Toll family have been identified. This family of type I transmembrane protein is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. TLR4, which is approximately 100 kDa, is expressed by myeloid lineage cells.

The MTS510 monoclonal antibody co-immunoprecipitates MD-2 (∽30 kDa) and TLR4 (∽100 kDa), and preferentially reacts with TLR4 that is associated with MD-2. In comparison, binding of the UT41 monoclonal antibody occurs with and without formation of the TLR4/MD-2 complex . Please contact eBioscience Technical Support for further information.
Specifications

Specifications

CD284 (TLR4)
UT41
Alexa Fluor 488
Conjugated
Murine
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
TLR-4, toll-like receptor 4
IgG1
RUO
Primary
Murine
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