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CD284 (TLR4), Alexa Fluor 488, clone: UT41, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-9041-80

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15362080

  • £105.99 / 25µg


Estimated Shipment date
from Supplier 20-12-2018
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Description

Description

Description: The UT41 monoclonal antibody was generated against BaF3 cells overexpressing mouse TLR4. So far, at least twelve members of the Toll family have been identified. This family of type I transmembrane protein is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. TLR4, which is approximately 100 kDa, is expressed by myeloid lineage cells.The MTS510 monoclonal antibody co-immunoprecipitates MD-2 (∽30 kDa) and TLR4 (∽100 kDa), and preferentially reacts with TLR4 that is associated with MD-2. In comparison, binding of the UT41 monoclonal antibody occurs with and without formation of the TLR4/MD-2 complex. Please contact eBioscience Technical Support for further information.Applications Reported: This UT41 antibody has been reported for use in flow cytometric analysis.Applications Tested: This UT41 antibody has been tested by flow cytometric analysis of mouse thioglycolate-elicited peritoneal exudate cells. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD284 (TLR4)
Monoclonal
0.5mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q9QUK6
Toll-like Receptor 4, ARMD10, CD284, TLR-4, TOLL, hToll, homolog of Drosophila toll
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Flow Cytometry
UT41
Alexa Fluor 488
Tlr4
Liquid
Tlr4
IgG1
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
21898
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