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CD284 (TLR4) Mouse anti-Human, Biotin, Clone: HTA125, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-9917-80

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15340110

  • £60.53 / 25µg


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For Research Use Only.


Description

Description

The HTA125 monoclonal antibody reacts with human Toll-like receptor 4 (TLR4). So far, at least ten members of the Toll family have been identified in humans. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. TLR4 is expressed by peripheral blood monocytes. HTA125 has been reported to immunoprecipitate human TLR4 (∽100 kDa) from transfected cells. Most TLR cell surface expression, especially TLR1 and TLR4, occurs at low levels on monocytes and at even lower levels on other cell types including granulocytes and immature dendritic cells (iDC). Furthermore, a relatively high degree of variability in TLR surface expression has been reported among normal donors.
Specifications

Specifications

CD284 (TLR4)
HTA125
Biotin
Conjugated
Murine
25μg
Store at 2-8°C. Do not freeze.
Monoclonal
Flow Cytometry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
TLR-4, toll-like receptor 4
IgG2a
RUO
Primary
Human
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