CD284 (TLR4) Mouse anti-Human, Biotin, Clone: HTA125, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-9917-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15350110

Quantity Price
1 £ 133.91 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Primary or Secondary Primary
Format Conjugated
Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias TLR-4, toll-like receptor 4
Isotype IgG2a
Antigen CD284 (TLR4)
Conjugate Biotin
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Quantity 100μg
Clone HTA125
Regulatory Status RUO
Host Species Mouse
Storage Requirements Store at 2-8°C. Do not freeze.

The HTA125 monoclonal antibody reacts with human Toll-like receptor 4 (TLR4). So far, at least ten members of the Toll family have been identified in humans. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. TLR4 is expressed by peripheral blood monocytes. HTA125 has been reported to immunoprecipitate human TLR4 (∽100 kDa) from transfected cells. Most TLR cell surface expression, especially TLR1 and TLR4, occurs at low levels on monocytes and at even lower levels on other cell types including granulocytes and immature dendritic cells (iDC). Furthermore, a relatively high degree of variability in TLR surface expression has been reported among normal donors.