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CD284 (TLR4) Monoclonal Antibody (HTA125), APC, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£88.75 - £240.00

Specifications

Antigen CD284 (TLR4)
Clone HTA125
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
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Product Code Brand Quantity Price Quantity & Availability  
15109926
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Affymetrix eBioscience
17-9917-42
100 Tests
£240.00
100 tests
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15538276
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Affymetrix eBioscience
17-9917-41
25 Tests This item is currently unavailable or has been discontinued.
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Description

Description

Description: The HTA125 monoclonal antibody reacts with human Toll-like receptor 4 (TLR4). So far, at least ten members of the Toll family have been identified in humans. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. TLR4 is expressed by peripheral blood monocytes. HTA125 has been reported to immunoprecipitate human TLR4 (∽100 kDa) from transfected cells. Most TLR cell surface expression, especially TLR1 and TLR4, occurs at low levels on monocytes and at even lower levels on other cell types including granulocytes and immature dendritic cells (iDC). Furthermore, a relatively high degree of variability in TLR surface expression has been reported among normal donors. Applications Reported: HTA125 has been reported for use in flow cytometric analysis. Applications Tested: This HTA125 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (1 μg) per test.

CD284 (TLR4) Monoclonal antibody specifically detects CD284 (TLR4) in Human samples. It is validated for Flow Cytometry.
Specifications

Specifications

CD284 (TLR4)
5 μL/Test
Monoclonal
Liquid
RUO
O00206
TLR4
Primary
4° C, store in dark, DO NOT FREEZE!
TLR4
HTA125
Flow Cytometry
APC
Mouse
Human
7099
IgG2a κ
Affinity chromatography
Antibody
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