CD284 (TLR4) Mouse anti-Human, APC, Clone: HTA125, eBioscience™

Mouse Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-9917-42

X100 tests Mouse anti human CD284 APC cloneHTA125

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.10000kg

Disclaimers: For Research Use Only.

Product Code. 15109926

Quantity Price
1 £207.00 / 100 tests
Estimated Shipment date
from Supplier 31-10-2016
Add to basket

Description and Specification


Antigen CD284 (TLR4)
Applications Flow Cytometry
Clone HTA125
Concentration 5μL (1μg)/test
Conjugate APC
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias TLR-4, toll-like receptor 4
Host Species Mouse
Isotype IgG2a
Quantity 100 tests
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The HTA125 monoclonal antibody reacts with human Toll-like receptor 4 (TLR4). So far, at least ten members of the Toll family have been identified in humans. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR4 physically associates with another molecule called MD-2, and together with CD14, this complex is responsible for LPS recognition and signaling. TLR4 is expressed by peripheral blood monocytes. HTA125 has been reported to immunoprecipitate human TLR4 (∽100 kDa) from transfected cells. Most TLR cell surface expression, especially TLR1 and TLR4, occurs at low levels on monocytes and at even lower levels on other cell types including granulocytes and immature dendritic cells (iDC). Furthermore, a relatively high degree of variability in TLR surface expression has been reported among normal donors.