CD283 (TLR3) Mouse anti-Human, Clone: TLR3.7, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9039-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15268137

Quantity Price
1 £ 78.88 / 25µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Primary or Secondary Primary
Regulatory Status RUO
Concentration 0.5mg/mL
Monoclonal or Polyclonal Monoclonal
Gene Alias TLR-3, toll-like receptor 3
Applications Flow Cytometry (Intracellular Staining)
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Host Species Mouse
Isotype IgG1
Clone TLR3.7
Quantity 25μg
Antigen CD283 (TLR3)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Storage Requirements Store at 2-8°C.
Format Purified
Conjugate Unlabeled

The TLR3.7 monoclonal antibody reacts with human Toll-like receptor 3 (TLR3). To date, at least twelve members of the Toll-like receptor family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. In the innate immune response, TLRs recognize molecular patterns associated with microbial pathogens and induce antimicrobial activity. TLR3 recognizes double-stranded (ds)RNA, induces the activation of NF-κB through MyD88-dependent and -independent pathways, and the production of type I interferons (IFNs). TLR3.7 suppressed poly(I):poly(C)-mediated IFN-β production by human fibroblasts naturally expressing TLR3 on their surface.