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CD279 (PD-1) Rat anti-Mouse, Clone: RMP1-14, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-9982-85

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15288847

  • £201.16 / 500µg


Estimated Shipment
02-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

This antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1 (Cat. No. 16-9985), RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants.
Specifications

Specifications

CD279 (PD-1)
RMP1-14
Unconjugated
Purified
IgG2a
RUO
Primary
Murine
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
Rat
500μg
Store at 2-8°C.
Monoclonal