CD279 (PD-1) Rat anti-Mouse, Clone: RMP1-14, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9982-85

500UG:ANTI-MOUSE CD279(PD-1)FUNCTIONAL GRADE

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288847

Quantity Price
1 £ 201.16 / 500µg
Estimated Shipment date
from Supplier 31-03-2017
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Description and Specification

Specification

Antigen CD279 (PD-1)
Format Purified
Formulation aqueous buffer, no sodium azide
Host Species Rat
Applications Flow Cytometry
Applications Functional Assay
Isotype IgG2a
Quantity 500μg
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone RMP1-14
Concentration 1mg/mL
Conjugate Unlabeled

This antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1 (Cat. No. 16-9985), RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants.