CD279 (PD-1) Rat anti-Mouse, Clone: RMP1-14, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9982-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288847

Quantity Price
1 £ 201.16 / 500µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Isotype IgG2a
Applications Flow Cytometry
Applications Functional Assay
Format Purified
Host Species Rat
Species Reactivity Mouse
Conjugate Unlabeled
Concentration 1mg/mL
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Antigen CD279 (PD-1)
Storage Requirements Store at 2-8°C.
Quantity 500μg
Regulatory Status RUO
Clone RMP1-14

This antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1 (Cat. No. 16-9985), RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants.