CD279 (PD-1) Rat anti-Mouse, Biotin, Clone: RMP1-30, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-9981-85

500UG ANTI-MOUSE CD279 (PD-1) BIOTIN

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15380140

Quantity Price
1 £ 207.0 / 500µg
Estimated Shipment date
from Supplier 13-12-2016
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Description and Specification

Specification

Antigen CD279 (PD-1)
Applications Flow Cytometry
Clone RMP1-30
Concentration 0.5mg/mL
Conjugate Biotin
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Pdcd1, Programmed cell death protein 1
Host Species Rat
Isotype IgG2b
Quantity 500μg
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The RMP1-30 antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. RMP1–30 does not block the binding of either B7-H1-Ig or B7-DC-Ig to PD-1 transfectants.