CD279 (PD-1) Mouse anti-Human, PerCP-eFluor 710, Clone: eBioJ105 (J105), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-2799-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15599226

Quantity Price
1 £ 81.63 / 25 tests
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Applications Flow Cytometry
Regulatory Status RUO
Isotype IgG1
Host Species Mouse
Clone eBioJ105 (J105)
Monoclonal or Polyclonal Monoclonal
Quantity 25 tests
Conjugate PerCP-eFluor 710
Format Conjugated
Gene Alias PD1
Species Reactivity Human
Concentration 5μL (0.25μg)/test
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen CD279 (PD-1)

The J105 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55kDa member of the CD28 immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells.
Costaining experiments suggest that eBioJ105 recognizes a different epitope than MIH4 (cat. 11-9969).