CD279 (PD-1) Mouse anti-Human, PerCP-eFluor 710, Clone: eBioJ105 (J105), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-2799-42

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15572696

Quantity Price
1 £ 208.18 / 100 tests
EU Stock 3
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Description and Specification

Specification

Quantity 100 Tests
Host Species Murine
Conjugate PerCP-eFluor 710
Species Reactivity Human
Format Conjugated
Clone eBioJ105 (J105)
Isotype IgG1
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Antigen CD279 (PD-1)
Applications Flow Cytometry
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.25μg)/test
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias PD1

The J105 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55kDa member of the CD28 immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells.
Costaining experiments suggest that eBioJ105 recognizes a different epitope than MIH4 (cat. 11-9969).