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CD279 (PD-1), PE-Cyanine7, clone: eBioJ105 (J105), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 25-2799-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15588526

  • £223.00 / 100 tests


EU Stock 12
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Description

Description

Fixation: Samples can be stored in IC Fixation Buffer (cat. 00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (cat. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of ""danger signals"" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Specifications

Specifications

CD279 (PD-1)
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q15116
PD1
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Rhesus Monkey
Flow Cytometry
eBioJ105 (J105)
PE-Cyanine7
PDCD1
Liquid
PDCD1
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
100135775, 5133
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