CD279 (PD-1) Mouse anti-Human, Clone: J121, eBioscience™

Mouse Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-2798-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg

Disclaimers: For Research Use Only.

Product Code. 15577436

Quantity Price
1 £ 186.31 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification


Host Species Mouse
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Format Purified
Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Western Blotting
Storage Requirements Store at 2-8°C.
Species Reactivity Human
Clone J121
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL
Primary or Secondary Primary
Regulatory Status RUO
Quantity 100μg
Antigen CD279 (PD-1)
Conjugate Unlabeled

This J121 monoclonal antibody reacts with human CD279 (programmed death-1, PD-1), a 55kDa member of the CD28 immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the CD279 ligands, CD274 (PD-L1, B7-H1) and CD273 (PD-L2, B7-DC). Evidence reported to date suggests overlapping functions for these two ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. More recently, therapies targeting the blockade of the CD279/CD274 pathway have become the focus for treatment of melanoma, renal cell cancer, Hodgkins’ lymphoma, and non-small cell lung carcinoma (NSCLC).

The J121 monoclonal antibody is not recommended for flow cytometry of human cells. For detection of human CD279 using flow cytometry please refer to clone eBioJ105 (J105).