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CD279 (PD-1) Mouse anti-Human, Clone: J121, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-2798-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15577436

  • £186.31 / 100µg


Estimated Shipment date
from Supplier 25-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

This J121 monoclonal antibody reacts with human CD279 (programmed death-1, PD-1), a 55kDa member of the CD28 immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the CD279 ligands, CD274 (PD-L1, B7-H1) and CD273 (PD-L2, B7-DC). Evidence reported to date suggests overlapping functions for these two ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. More recently, therapies targeting the blockade of the CD279/CD274 pathway have become the focus for treatment of melanoma, renal cell cancer, Hodgkins’ lymphoma, and non-small cell lung carcinoma (NSCLC).

The J121 monoclonal antibody is not recommended for flow cytometry of human cells. For detection of human CD279 using flow cytometry please refer to clone eBioJ105 (J105).
Specifications

Specifications

CD279 (PD-1)
J121
Unlabeled
Purified
IgG1
RUO
Primary
Human
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100μg
Store at 2-8°C.
Monoclonal