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CD279 (PD-1) Mouse anti-Human, Clone: J116, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-9989-38

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15587836

  • £1161.07 / 5mg


Estimated Shipment date
from Supplier 01-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The J116 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55kDa member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.
Description & Specifications

Specifications

CD279 (PD-1)
J116
Unlabeled
aqueous buffer, no sodium azide
Murine
5mg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
Purified
PD1
IgG1
RUO
Primary
Human