CD279 (PD-1) Mouse anti-Human, Clone: J116, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9989-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15238857

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Host Species Mouse
Isotype IgG1
Format Purified
Antigen CD279 (PD-1)
Quantity 25μg
Regulatory Status RUO
Applications Functional Assay
Formulation aqueous buffer, no sodium azide
Clone J116
Gene Alias PD1
Concentration 1mg/mL
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human
Primary or Secondary Primary
Conjugate Unlabeled
Storage Requirements Store at 2-8°C.

The J116 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55kDa member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.