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CD279 (PD-1) Mouse anti-Human, Clone: J116, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9989-80

UNSPSC : 12352203

Code : Z2

Additional Details : Weight : 0.50000kg

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Product Code. 15181756

  • £60.53 / 25µg


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For Research Use Only.


Specifications

Description

The J116 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55kDa member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.
Description & Specifications

Specifications

CD279 (PD-1)
J116
Unlabeled
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal
Immunoprecipitation
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
PD1
IgG1
RUO
Primary
Human