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CD279 (PD-1) Mouse anti-Human, APC, Clone: MIH4, eBioscience™

Mouse Monoclonal Antibody

£100.00 - £191.00

Specifications

Antigen CD279 (PD-1)
Clone MIH4
Target Species Human
Conjugate APC
Isotype IgG1, kappa
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Products 2
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Product Code Brand Quantity Price Quantity & Availability  
15558286
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Affymetrix eBioscience
17-9969-41
25 Tests £100.00
25 tests View alternative products
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Estimated Shipment
27-10-2020
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15568286
View Documents
Affymetrix eBioscience
17-9969-42
100 Tests £191.00
100 tests View alternative products
Save Up to 
»
Estimated Shipment
28-10-2020
Please to purchase this item. Need a web account? Register with us today!
Description

Description

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of ""danger signals"" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Specifications

Specifications

CD279 (PD-1)
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
MIH4
APC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.