missing translation for 'onlineSavingsMsg'
Learn More

CD279 (PD-1) Armenian Hamster anti-Mouse, PE-Cy7, Clone: J43, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 25-9985-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

 View more versions of this product

Product Code. 15381010

  • £68.40 / 25µg


EU Stock 6
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

The J43 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2.
Specifications

Specifications

CD279 (PD-1)
J43
PE-Cyanine7
Conjugated
IgG
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Armenian Hamster
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal