CD279 (PD-1) Armenian Hamster anti-Mouse, Clone: J43, Functional Grade, eBioscience™

Armenian Hamster Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9985-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15228857

Quantity Price
1 £ 201.16 / 500µg
EU Stock 6
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Description and Specification

Specification

Isotype IgG
Gene Alias PD1
Format Purified
Concentration 1mg/mL
Applications Flow Cytometry
Applications Functional Assay
Clone J43
Host Species Armenian Hamster
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled
Primary or Secondary Primary
Formulation aqueous buffer, no sodium azide
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Quantity 500μg
Antigen CD279 (PD-1)
Species Reactivity Mouse

The J43 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2.