CD279 (PD-1) Armenian Hamster anti-Mouse, Clone: J43, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9985-85

500UG:ANTI-MOUSE CD279 (PD-1) PURIFIED 500 UG

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15228317

Quantity Price
1 £ 201.0 / 500µg
Estimated Shipment date
from Supplier 22-02-2017
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Description and Specification

Specification

Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Armenian Hamster
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Regulatory Status RUO
Species Reactivity Mouse
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled
Antigen CD279 (PD-1)
Isotype IgG
Quantity 500μg
Storage Requirements Store at 2-8°C.
Clone J43
Concentration 0.5mg/mL

The J43 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2.