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CD278 (ICOS) Monoclonal Antibody (7E.17G9), eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£55.25 - £215.00
Specifications
Antigen | CD278 (ICOS) |
---|---|
Clone | 7E.17G9 |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15154355
|
Affymetrix eBioscience
14-9942-85 |
500 μg |
£215.00
500µg |
Estimated Shipment: 08-05-2024 Log in to see stock. |
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15278257
|
Affymetrix eBioscience
14-9942-81 |
50 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: The 7E.17G9 monoclonal antibody reacts with mouse ICOS (Inducible COStimulatory molecule), a T cell specific molecule and a third member of the CD28/CTLA-4 family. A homodimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1 and is thought to play a protective role in inflammatory autoimmune diseases. ICOS may be involved in the development of Th2 cells. Applications Reported: 7E.17G9 has been reported for use in flow cytometric analysis and for inhibition of ligand binding in functional assays (please use Functional Grade purified, cat. 16-9942). Applications Tested: The 7E.17G9 antibody has been tested by flow cytometric analysis of unstimulated and Con A activated (3 day) mouse splenocytes and can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.
ICOS (CD278) encodes a protein that is a member of the CD28 and CTLA-4 cell-surface receptor family. It functions as a homodimer and has a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation. ICOS has been linked to various disorders, including Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.Specifications
CD278 (ICOS) | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115 | |
ICOS | |
Primary | |
4° C | |
ICOS |
7E.17G9 | |
Flow Cytometry | |
Unconjugated | |
Rat | |
Mouse | |
Q9WVS0 | |
54167 | |
IgG2b κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.