missing translation for 'onlineSavingsMsg'
Learn More
Learn More
CD278 (ICOS) Monoclonal Antibody (ISA-3), eFluor™ 450, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£74.50 - £230.00
Specifications
| Antigen | CD278 (ICOS) |
|---|---|
| Clone | ISA-3 |
| Concentration | 5 μL/Test |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15569846
|
Affymetrix eBioscience
48-9948-42 |
100 Tests |
£230.00
100 tests |
In Stock Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
|
15559846
|
Affymetrix eBioscience
48-9948-41 |
25 Tests |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
||||||
Description
Description: The ISA-3 monoclonal antibody reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1 and AILIM. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. Human ICOS has a relative molecular mass of 55-60 kDa, composed of 27 kDa and 29 kDa chains. Human ICOS on activated T cells has potent costimulatory activity for T cell activation and is required for humoral immune responses, in particular for memory B cell and plasma cell generation. ICOS binds to its ligand, B7h/B7RP-1 expressed on activated APCs (antigen presenting cells) and on a number of inflamed peripheral tissues. Plate-bound ISA-3 is costimulatory for T cells and induces production of IL-4, IL-5, IL-10 and other cytokines, but not IL-2. ISA-3 has the same reactivity pattern and characteristics as F44. ISA-3 was generated against the human ICOS antigen. C398.4A, anti-mouse ICOS/H4 (cat. 14-9949-82), was shown to cross-react with human ICOS but binds to an epitope different from ISA-3. C398.4A stains activated cells brighter than ISA-3; however, it also exhibits higher staining of non-activated human peripheral blood or isolated PBMC. To achieve the brightest staining of ICOS on activated human T cells, please use 13-9948-82 or 12-9948-42 rather than 11-9948-42. Applications Reported: This ISA-3 antibody has been reported for use in flow cytometric analysis.
CD278 (ICOS) Monoclonal antibody specifically detects CD278 (ICOS) in Human samples. It is validated for Flow Cytometry.Specifications
| CD278 (ICOS) | |
| 5 μL/Test | |
| Monoclonal | |
| Liquid | |
| RUO | |
| Q9Y6W8 | |
| ICOS | |
| Primary | |
| 4° C, store in dark, DO NOT FREEZE! | |
| ICOS |
| ISA-3 | |
| Flow Cytometry | |
| eFluor 450 | |
| Mouse | |
| Human | |
| 29851 | |
| IgG1 κ | |
| Affinity chromatography | |
| Antibody |
For Research Use Only.