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CD278 (ICOS) Monoclonal Antibody (C398.4A), PE-Cyanine7, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 25-9949-82

146.67 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.



Code : NEW

Additional Details : Weight : 0.09500kg

Product Code. 15578696

  • £220.00 / 100µg
Estimated Shipment: 10-04-2024
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Description

Description

Description: The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL). Applications Reported: This C398.4A antibody has been reported for use in flow cytometric analysis. Applications Tested: This C398.4A antibody has been tested by flow cytometric analysis of stimulated mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL.

CD278 (ICOS) Monoclonal antibody specifically detects CD278 (ICOS) in Mouse, Rat, Rhesus Monkey samples. It is validated for Flow Cytometry.
Specifications

Specifications

CD278 (ICOS)
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9R1T7, Q9WVS0
ICOS
Affinity chromatography
RUO
54167, 64545, 705788
4° C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
C398.4A
PE-Cyanine7
ICOS
Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115
Armenian Hamster
100 μg
Primary
Mouse, Rat, Rhesus Monkey
Antibody
IgG
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