CD278 (ICOS) Armenian Hamster anti-Mouse, Rat, Biotin, Clone: C398.4A, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-9949-82


UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg

Disclaimers: For Research Use Only.

Product Code. 15340130

Quantity Price
1 £132.00 / 100µg
Estimated Shipment date
from Supplier 27-10-2016
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Description and Specification


Antigen CD278 (ICOS)
Applications Flow Cytometry
Clone C398.4A
Concentration 0.5mg/mL
Conjugate Biotin
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Inducible T-cell COStimulator
Host Species Armenian Hamster
Isotype IgG
Quantity 100μg
Regulatory Status RUO
Species Reactivity Mouse, Rat
Storage Requirements Store at 2-8°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL).