CD278 (ICOS) Armenian Hamster anti-Mouse, Rat, Biotin, Clone: C398.4A, eBioscience™

Armenian Hamster Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-9949-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15340130

Quantity Price
1 £ 103.33 / 100µg
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Conjugated
Monoclonal or Polyclonal Monoclonal
Antigen CD278 (ICOS)
Quantity 100μg
Clone C398.4A
Isotype IgG
Storage Requirements Store at 2-8°C. Do not freeze.
Conjugate Biotin
Applications Flow Cytometry
Concentration 0.5mg/mL
Gene Alias Inducible T-cell COStimulator
Host Species Armenian Hamster
Species Reactivity Mouse, Rat
Regulatory Status RUO
Primary or Secondary Primary

The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL).