CD273 (B7-DC) Rat anti-Mouse, PE, Clone: TY25, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5986-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15269229

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Description and Specification

Specification

Applications Flow Cytometry
Host Species Rat
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG2a
Primary or Secondary Primary
Antigen CD273 (B7-DC)
Monoclonal or Polyclonal Monoclonal
Concentration 0.2mg/mL
Regulatory Status RUO
Format Conjugated
Conjugate PE
Quantity 100μg
Species Reactivity Mouse
Clone TY25
Gene Alias B7DC, PD-L2, PDL-2, PDL2
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

The TY25 monoclonal antibody reacts with mouse B7-DC/PD-L2. B7-DC, a member of the B7 family, has a predicted molecular weight of ∽25kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by sub-populations of dendritic cells, monocytes and macrophages. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, but binds PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. TY25 is a useful tool to study the exact function of B7-DC/PD-L2 in APC/T cell interaction and to characterize the expression pattern of this molecule in mouse.